New Science Shows the Hormone Relationship in Migraines

Research Article by Lyle Henry

For many years migraine researchers have known there is a hormone connection to migraines. We can safely say that most migraines occurring in men, women, and children are caused by the body's inability to properly manage the changes in hormone production.

The more precise cause of migraines may be seen as a change in specific neurochemicals that are released during phases of hormone production. These neurochemicals affect the trigeminal nerve vascular system and sets into motion a progression of events, the outcome of which is a painful migraine headache and associated aura, nausea and vomiting.

DNA The reason some people get migraines can be found in the DNA makeup as an inherited gene. This gene has been identified and labeled as MTHFR and is found in the mitochondria of specific cells. These cells are the hormone producing cells for estrogen and progesterone for both men and women (yes, men produce the same hormones as women).

These cells receive their "production" orders by way of other hormones known as "messenger" hormones that are produced and secreted by the pituitary gland. The way these cells know that the messenger hormones are for them is through specialized proteins that are on the outside of the cell membrane called hormone receptors.

Deep Secrets of Migraines

Migraines occur when various hormone levels of the body fluctuate and most often when the "messenger" hormones are secreted from the pituitary gland into the blood stream to be received by the aforementioned specific cells in the body that have the migraine gene. For a still unknown reason, there is an adverse reaction in these cells that causes the production of neurochemical identified as CGRP to occur.

How Do Hormones Cause Migraines?

Hormones don't in the true sense of cause and effect; however, when we use the analogy of an automobile we can start to understand the relationship. Gasoline, for example does not make the car go; rather, gasoline makes the engine run which rotates the transmission gears, which make the wheels turn. Hormones are like the gasoline in that they start a reaction which results in the wheels turning that ends with a migraine.

To say that estrogen or progesterone is the cause of a migraine is a misunderstanding of the effect of hormones on migraines. This misunderstanding has led to the prescribing additional hormones as a treatment for migraines. We can readily see the adverse effect of hormones on migraine when we realize that birth control pills, which are hormones, generally cause migraine headaches.

Migraines occur outside the brain in what is called the trigeminal nerve vascular system. Those who have had migraine headaches can easily draw the path of this system as it starts at the temples and runs forward to branch out behind the eyes and down the jaw line. This system is comprised of hair-like nerve fibers that are intertwined with tiny blood vessels.

The pain of a migraine headache occurs when these tiny blood vessels dilate and begin to swell and expand to the point where they are actually putting pressure on the nerve endings. We often feel throbbing pain as the blood fills these vessels and pinch on nerves.

It is the neurochemical CGRP that causes the blood vessels to dilate and expand. To make matters worse, when the nerve fibers become irritated, they react in a way that can cause an increase in the level of CGRP in a round-robin effect that increases the pain level and the duration of a migraine attack.

To learn more see Tuliv Migraine Research.

Migraine Prevention

Thank you for your invitation to write about Migraine Defense.

Migraine Defense has become an essential component of my daily migraine preventive regime. Without it, I would experience non-stop, chronic head pain and much more frequent and severe migraines. I know Migraine Defense is responsible for this huge improvement in my life because I stopped using it for a several weeks to see what would happen and my constant debilitating head pain returned along with my more severe migraine attacks.

With Migraine Defense I am able to participate in my life fully again. My daily pain is gone and my migraines are reduced to once or twice a month and are easily treated with triptan medication. I'm able to work a part-time job that I love. I can meet my social and family obligations without fear of having to cancel at the last minute. I can be there for my daughter when she needs me, rather than my depending on her while I lie in the dark in the grip of pain. Recently my husband and I started ballroom dance lessons, something I couldn't even imagine doing a year ago. We just participated in a public showcase and now plan to enter a dance competition.

For a life-long sufferer of migraine whose condition had gradually devolved into one of chronic pain, ranging from somewhat debilitating to soul destroying, this is a pretty heady stuff (sorry for the pun). Migraine Defense has proven itself to be life restoring for me.

Sincerely,

Melanie Symonds

 

Resveratrol: What Our Research Shows

Research Article by Lyle Henry

There is much talk today about the next "fountain of youth" discovery - Resveratrol. Resveratrol is a natural substance found in many plants, including grapes, peanuts and Japanese Knotweed. The introduction of resveratrol as a "cure-all" with such claims as its being an antioxidant, anti-inflammatory anti-cancer, antiviral, anti-aging, as well as a weight-loss and performance enhancing panacea, has given rise to its recent popularity.

We are concerned with the effect that resveratrol has on the occurrence of migraines.

Resveratrol is a basic substance found in red wine - in fact, that is how the properties of resveratrol were discovered; however, in resveratrol dietary supplements the concentration is much higher. A 5-ounce glass of red wine provides about 0.30-1.07 mg of resveratrol; by comparison, a dietary supplement can provide 100 mg of resveratrol per capsule. Since we know that red wine can easily trigger migraine headaches, it follows that taking resveratrol could do the same.

Headache is a reported side effect of taking resveratrol. These headaches can start within a day or two of first taking resveratrol and can continue for an extended length of time after stopping resveratrol. This is true even for those who do not get migraines.

The reason why resveratrol triggers migraines is that it promotes vasodilation by enhancing the production of a naturally occurring substance in the body called nitric oxide. If you have been following the migraine research of Tuliv, you have seen that nitric oxide is one of the most prominent factors involved in a migraine headache.

Our recommendation is to avoid resveratrol if you get migraines. If you are going to try it, do so with a controlled test and keep track of your results. You may want to print and use our headache dairy for such a purpose.

To learn more about what to avoid and why, please see Knowing Your Triggers. If you are in doubt about a supplement or something in your diet, please feel free to email us at Questions@Tuliv.net for assistance.

Migraines can be prevented - Read More.

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References for this Article:

Resveratrol Increases Nitric Oxide Synthase, Induces Accumulation of p53 and p21WAF1/CIP1, and Suppresses Cultured Bovine Pulmonary Artery Endothelial CellProliferation by Perturbing Progression through S and G21 -
Department of Biochemistry and Molecular Biology [T-c. H., J. M. W.] and Brander Cancer Research Institute [G. J., Z. D.], New York Medical College, Valhalla, New York 10595
http://cancerres.aacrjournals.org/cgi/content/abstract/59/11/2596

Resveratrol stimulates nitric oxide production by increasing estrogen receptor -Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. - Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM. Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
http://www.biotivia.com/bioforteresveratrol/evidence/resveratrolstimulatesnitricoxideproduction.html

Upregulation of endothelial nitric oxide synthase (eNOS) gene expression after 24 to 72 hours incubation. Resveratrol-enhanced. eNOS expression and activity -
Dirk Taubert, MD, PhD, Reinhard Berkels, PhD, Department of Pharmacology University of Cologne, Cologne, German- 2003
http://www.circ.ahajournals.org/cgi/reprint/107/11/e78.pdf

Migraine Patterns - Time of the Day

Research Article by Lyle Henry

This is the first in a series of articles on migraine patterns that will explore the occurrences of migraines based on the time of day, day of the month, and age of the person. In this first article we will address the time of day.

Time of the Day

"What time of the day do your migraines start?" is one of the questions we ask someone who gets migraines. It is one of the most important questions in helping to determine what is happening inside the body to invoke a migraine.

A very common answer is "during the night;" however, when we ask for the exact time, most reply, "Around 4 AM." The other two most frequent replies as to when a person gets a migraine are "Shortly after getting up in the morning" (full-blown by noon) and "Sometime in the late afternoon."

These time patterns actually coincide with hormone changes in the body. When we look at which hormones fluctuate around these times, we find the hormone melatonin, from the pineal gland, and the hormone cortisol, from the adrenal gland.

The body begins producing melatonin (the hormone that helps us sleep) generally around 4 PM and it stops producing around 4 AM. Even though we see that this corresponds to times of migraines, we cannot jump to the conclusion that this hormone is a cause of migraines; rather, we must look at the actions of this hormone to see their effect on migraines.

The level of melatonin in the body affects how other hormones function, namely the two hormones that we are most interested in when researching the cause of migraines: Lutenizing Hormone (LH) and Folic Stimulating Hormone (FSH) (in both male and female bodies). These are hormones that have receptors on the cells that contain the known gene for migraines. Since we already know that fluctuations in the level of these hormones can invoke monthly menstrual migraines in women, we can reason that we are dealing with similar reactions as the cause of these other migraine occurrences.

Taking a melatonin supplement before bed can be helpful for some people in preventing or lessening the severity of early morning migraines. For those who take Tuliv Migraine Defense regularly and still may have some break-though 4 AM type migraines, adding a 1 mg time-released melatonin supplement at bedtime works synergistically to prevent these headaches.

What about a migraine that begins after we get up in the morning? Well, just as melatonin helps us sleep, the hormone cortisol helps us wake up and start the day. Cortisol is a powerful hormone used by the body to make us more alert, especially while under stress. Our research has shown that cortisol may be the underlying cause of stress headaches.

When we trace how cortisol works in the body, we see that it also has an effect on the LH and FSH hormones receptors on the "migraine gene" cells and so we again feel we are dealing with the same set of principles that are at the center of the cause of migraines.

We have mentioned three different times of the day when migraines are most likely to start, and yet we have named only two different hormones. That is because melatonin also appears to be involved in the occurrence of afternoon headaches.

Have you ever noticed how you begin to feel tired or let down in the late afternoon? That is when melatonin starts to enter the body. Melatonin is produced from serotonin, that is to say the pineal gland converts serotonin to melatonin. We have already mentioned above how melatonin affects the "migraine gene" cells. Although some migraine researchers see the lack of serotonin as the problem, what may actually be occurring is the reaction of melatonin after it has been converted from serotonin.

For the most part, Tuliv Migraine Defense prevents migraine no matter what time of the day; however, if this is not complete for all afternoon headaches, we may recommend adding the supplement 5-HTP, which appears to help increase serotonin or at least stabilize the depletion of it. Some research has indicated that 5-HTP alone may be helpful in preventing migraines or at least in reducing their frequency and severity.

The time when migraines occur reveals a great deal of information about what is happening in the body and points to the cause of migraines. By understanding and using this information, we can find natural ways to help prevent migraines. At Tuliv, we are dedicated to helping you find your best solution for a migraine-free life.

What time of the day do most of your migraines start? If you are unsure of any pattern, then please print a copy of our Migraine Diary and track your migraines for the next month and see what you find. We will be happy to go over the results with you, either by phone (1-866-367-5953) or by email Questions@Tuliv.net

We welcome your questions and comments. You can contact Lyle Henry directly by email at Lyle@Tuliv.net or by calling 1-866-367-5953. There is no cost or obligation for his services.